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ProgestPure is a highly bioavailable and natural topical progesterone serum providing 20 mg of bioidentical progesterone in each 1 ml serving. It is made from yams - it is then modified in the lab for the progesterone molecule to resemble a human progesterone molecule.


  • Natural bioidentical progesterone can normalize hormone imbalances with fewer side-effects than synthetic progestins.
  • Reproductive age- Supporting progesterone levels in the body may increase the likelihood of a healthy cycle.
  • Menopausal / post-menopausal age- Supporting progesterone levels in the body may help make this significant life change more pleasant.

Made with non-GMO ingredients. This product is free of parabens, mineral oil, and petroleum. 

 Suggested Use*:

  •  Apply 1-2 times per day to smooth skin areas, such as wrists, inner arms or thighs, throat, neck, abdomen or chest, or
  • as directed by a health care practitioner.
  • For optimal use, rotate the areas of application.
  • Menstruating women: Apply 1 ml of ProgestPure once or twice per day on days 14 through 27 of the menstrual cycle, or as directed by a health care professional.
  • Menopausal and post-menopausal women: Apply 1 ml of ProgestPure once or twice per day for 25 consecutive days, followed by a 5-day break, or as directed by a health care professional.

Note: Consult your functional doctor or naturopath for dosage instructions based on your specific hormone levels.

*Results are individual and depend on your health status.

For a full description:




"Proposition 65, the Safe Drinking Water and Toxic Enforcement Act of 1986" was originally intended to protect drinking water sources from chemicals known to cause cancer, birth defects or other reproductive harm, and to inform citizens about exposures to such chemicals. Each year the Governor posts a list of chemicals “known to the state to cause cancer or reproductive toxicity .”

Progesterone is on the list.

Progesterone is a hormone that actually prevents cancer, it also helps with your thyroid, sleep, cycle and moods. It It is necessary for a healthy pregnancy and for bone health. Progesterone also helps reduce the typical symptoms of menopause (mood changes, hot flashes, insomnia, weight gain, thyroid disfunction, loss of libido, etc...)

There are four major flaws in the study that caused progesterone to be added to the Prop 65 warning list:  

1- The vast majority of the studies implicating progesterone were done on SYNTHETIC progesterone (progestins and other progesterone-like compounds called progestagens). These studies were NOT based on BIO-IDENTICAL progesterone (as used in our ProgestPure).  

Progestins and progestagens are similar in molecular structure to progesterone, but when they bind to progesterone receptors, their effects are amplified and more likely to cause abnormal responses– just like the ones in birth control pills.

2- The majority of the studies were done in combination with synthetic estrogens. Again,  ProgestPure does not use ANY synthetic hormones.

3-  The few studies done on bio-identical progesterone were done with excessive and unreal doses (from 10 times to 10000 times the standard recommended dose).

4- No studies were done using transdermal creams. Only oral, injected and suppository forms were used. This is important to note because hormones absorbed through the skin are metabolized differently than hormones that are administered via other means. 

Click HERE to view the study that wrongly implicated bio-identical progesterone.

We were very surprised to hear that our product would bear such a warning, despite it being one of the purest bio-identical progesterone oils available.

We created this product despite the law requiring this warning. We did it because we know how many women will experience relief of their painful symptoms. And, because we know that estrogen dominance is one of the leading causes of breast, uterine, ovarian and thyroid cancers.

Please note that our team personally use ProgestPure. 

If you have any further questions about this product please email us at



Customer Reviews
4.9 Based on 138 Reviews
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Sandy F.
United States United States
ProgestPure Works

I have been using ProgestPure for a month. It does work. I was on HRT a year ago I went off the prescription meds. I have been trying different natural meds for post menopause. I have tried creams, pills, and oral drops. Nothing has worked as good as ProgestPure. I have cut back on the dosage trying to make the bottle last longer using 50 ml drops instead 75. I am having some night sweats. Needless to say I will be ordering again and sticking to 75 dosage. I do have to use it twice a day. I’m not as done with menopause I’d like to be. ProgestPure is the best I have found.

Hormone Balance Nutritionals

Thank you for your review Sandy :)

Jennifer E.
United States United States

It helps me to sleep at night!

Hormone Balance Nutritionals

That is significant Jennifer!

Deborah H.
United States United States
Peace of mind

Since using ProgestPure, I have noted my mind is calmer and I am sleeping better!! Also noted my chin hair growth slowed down. WOW!

Hormone Balance Nutritionals

So glad to hear of these positive changes

Allison V.
United States United States
Clean option for progesterone replacement

For those looking for a "clean" option for progesterone replacement this is an excellent choice. This also come in very small packaging so if you have concerns with storage then this is also an excellent choice for that reason as well. The only downside to this product is the dosing. If you require larger amounts of progesterone then you may find that the amount of skin surface area required for your dosage is daunting, LOL! One dropper full of 20mg is just about the amount equivalent to rubbing it in on my thighs or forearms. It does dry quickly and this is an issue with dream bases as well. However other companies offer different percentages of progesterone per the same amount of base material (such as oil or cream). Something to keep in mind if you require a higher dosage and a high maintenance self care routine :) Applying and allowing the oil to dry takes about 10 minutes for me each evening. Overall I'm very impressed and thankful to have this product!

Hormone Balance Nutritionals

Thank you for all of your feedback Allison. So glad you are liking our ProgestPure

Amber R.
United States United States
Quality product

Great product, has made a significant difference for me in easing my symptoms of low progesterone, fast shipping too!

Hormone Balance Nutritionals

Very nice Amber